Chemical Warfare Secrets Almost Forgotten
Experimental Procedures
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Frequent recording of vital signs is highly important
Volunteers compare effects of LSD after test ends
Dr. Van Sim volunteers to breathe sarin gas
Clinical team watches 4 volunteers in simulated Observation Post for 72 hrs
Sp-5 Morrow times arithmetic test
Volunteer feels very relaxed after THC
BZ subject cannot sort cards
Mrs. Shuette records auditory acuity
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Basic range-finding studies were conducted with a variety of potential incapacitating agents, in order to identify those with desirable characteristics such as potency, speed of action, duration, comparative effectiveness by various routes of administration and variability of responses among subjects.
A safe environment for testing was required to allow subjects to become familiar with planned test procedures and nature of effects to be expected, as well as to allow staff to establish reliable pre-test physiological and performance baselines.
The presence of registered nurses, and creation of padded individual rooms and a larger area containing padded individual cubicles, nursing station and open area for meals and recreation (card playing and TV watching) created a safe and functional environment in which to conduct tests that sometimes required several days to complete.
Continuous observation, detailed descriptive notes and frequent performance testing of various abilities at scheduled intervals, together with interviews and notes by the responsible physician, plus documentation by closed circuit television tape-recording, all combined to create a detailed record of test results for each subject. Scores and behavioral ratings for each volunteer were combined in a single formatted clinical folder.
Data reduction and statistical analysis of results (typically involving 4-6 subjects at each of several dose levels) helped researchers to compile quantitative profiles for each agent.
A safe environment for testing was required to allow subjects to become familiar with planned test procedures and nature of effects to be expected, as well as to allow staff to establish reliable pre-test physiological and performance baselines.
The presence of registered nurses, and creation of padded individual rooms and a larger area containing padded individual cubicles, nursing station and open area for meals and recreation (card playing and TV watching) created a safe and functional environment in which to conduct tests that sometimes required several days to complete.
Continuous observation, detailed descriptive notes and frequent performance testing of various abilities at scheduled intervals, together with interviews and notes by the responsible physician, plus documentation by closed circuit television tape-recording, all combined to create a detailed record of test results for each subject. Scores and behavioral ratings for each volunteer were combined in a single formatted clinical folder.
Data reduction and statistical analysis of results (typically involving 4-6 subjects at each of several dose levels) helped researchers to compile quantitative profiles for each agent.
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Documenting a Lost Decade of Clinical Research
© 2006/2007
J.S. Ketchum
J.S. Ketchum
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